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Crohn’s Disease: Unique Challenges in a Longitudinal Family Study

Crohn’s disease (CD) is on the rise.  A form of inflammatory bowel disease affecting the gastrointestinal (GI) tract, CD causes abdominal pain, diarrhea, fever, and weight loss. Complications like bowel obstruction may occur, and those afflicted with CD have a higher risk of bowel cancer..

Sample Collection for Pediatrics Studies: Overcoming Technical and Logistical Obstacles

Therapeutic safety and efficacy in pediatric populations is both an important and underdeveloped aspect of translational and clinical health research. Pediatric physiology differs considerably both within the pediatric cohort and relative to the adult population, and studies conducted in pediatric populations yield different results than ones conducted using adult cohorts.

Rare Disorders: Rapid Research on Small Patient Populations

More than 300 million people live with at least one of 6,000+ identified rare diseases. Most of these diseases are chronic, degenerative, and they occasionally result in early death. A majority of rare diseases are genetic, with symptoms first arising during childhood.

Specialized At-Home Sample Acquisition Rapid Research on Small Patient Populations

In recent decades, rapid progress in science and technology has introduced increasingly precise and accurate tools for exploring potential therapeutic avenues. As scientists probe deeper into the inner workings of health and disease, the questions they ask become more specific, the studies they design become more intricate, and their sampling criteria becomes more stringent.

Seeking a Cure for Sickle Cell Disease

Sickle cell disease (SCD) refers to a collection of blood disorders that are mostly hereditary. SCDs generally arise from mutations in hemoglobin-encoding genes that often lead to red blood cells (RBCs) exhibiting a characteristic rigid sickle-like shape. The majority of sickle cell disease cases occur in populations with Sub-Saharan African genetic profiles, as well as in individuals with Indian and Arabian backgrounds.

Cancer and the Microbiome

The microbiome is an essential player in human health and disease. Gut microbiota dysbiosis associates with several cancers due to microbial products that cause inflammation, oncogenic gene expression changes, or genetic material destruction.  For example, people with colorectal cancer have different microbes in the tumor microenvironment than in adjacent healthy mucosa.

Fox News Coverage on the Coronavirus Pandemic

Phlebotomist Teams Assisting Researchers in Select Cities Transcript: Trace Gallagher: Well, phlebotomists just may be the unsung heroes in the fight against COVID-19. Teams of licensed phlebotomists in select cities are suiting up in protective gear and masks and heading into homes of former coronavirus patients.

StartUp Health 2020

Transcript: Logan Plaster: Founder and CEO of Sanguine Biosciences. Brian, why don’t you to come on in? Great to see you. Brian Neman: Great to see you. How are you? Logan Plaster: Good, good, good. Take a seat. Grab the microphone and happy to have you joining us live in the Startup Health studio.

Simplifying Patient Participation

  Research depends on samples from patients and healthy volunteers. However, obtaining biospecimens from human subjects can be a challenge for researchers and patients alike. Home-based specimen collection directly connects patients to researchers, while alleviating the burden of travel to secondary sites.